Expression of NONHSA1254644 in lung adenocarcinoma and its clinical significance

VernacularTitle:NONHSA1254644在肺腺癌中的表达及其临床意义
Author: Yixian ZHOU ^{1
,

2} ; Jun WANG ; Dan HE ; Chaojun DUAN ; Qun XIE
Author Information

1. 410006长沙,湖南省中医药研究院附属医院超声科
2. 410007长沙,湖南中医药大学第一附属医院内分泌科
Keywords: Lung neoplasms/GE; Adenocarcinoma/GE; RNA,long noncoding/GE
From: Journal of Chinese Physician 2018;20(5):664-666
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of long non-coding RNA NONHSA1254644 in lung adenocarcinoma and its clinical significance.Methods 99 cases of lung adenocarcinoma and the adjacent tissues as well as clinical data was collected.The expression level was detected by quantitative realtime polymerase chain reaction (qRT-PCR).Then the relationship between the expression level and the clinical parameters was analyzed.Cell counting kit-8 (CCK8) was used to investigate its effect of lung adenocarcinoma cell line A549 on proliferation.Results The expression of NONHSA1254644 was down-regulated in lung adenocarcinoma,and its expression was positively correlated with the differentiation of patients.The overexpression of NONHSA1254644 could inhibit the proliferation of A549 cells.Conclusions NONHSA1254644 is involved in the development and progression of lung adenocarcinoma.