Vacuolar H+-ATPase regulates vaginal microenvironment
10.3760/cma.j.issn.1008-1372.2018.04.013
- VernacularTitle:空泡型质子泵对阴道微环境的调节及意义
- Author:
Che XU
1
;
Ailuan LAI
;
Yurong ZHAO
Author Information
1. 首都医科大学附属复兴医院妇产科
- Keywords:
Vacuolar proton-translocating ATPases/ME;
Estradiol/BL;
Follicle stimulating hormone/BL;
Vagina/PH/UL
- From:
Journal of Chinese Physician
2018;20(4):528-530,534
- CountryChina
- Language:Chinese
-
Abstract:
Objective The purpose of this study was to develop the mechanism of vacuolar H+-ATPase regulation of vaginal microenvironment.Methods In this research,53 women were divided into three groups.Their age,serum estradiol (E2),serum follicle stimulating hormone (FSH),vaginal pH value,and mRNA expression of vacuolar H +-ATPase (VHA) on the ectocervical-vaginal epithelial cells were analyzed.Results (1) As serum E2 levels decreased,the vaginal pH values increased and VHA mRNA declined (P ＜ 0.01).(2) Immunohistochemistry scores decreased in the three groups.VHA expression decreased in human ectocervical-vaginal epithelial tissues except basal cells.(3) The expression of VHA was positive correlated with estradiol,while negative correlated with age and vaginal pH value (P ＜ 0.01).Conclusions Estradiol could regulate the genetic transcription and synthetic of VHA protein under vaginal microenvironment.
