Expression and correlation of Fascin-1 and EGFR in hormone receptor-positive breast cancer
10.3760/cma.j.issn.1008-1372.2018.04.011
- VernacularTitle:激素受体阳性乳腺癌中Fascin-1和EGFR的表达及关系
- Author:
Chaoqun WANG
1
;
Bifei HUANG
;
Yan WANG
;
Yongming ZHAO
;
Zuliang HU
;
Guinv HU
;
Qian WANG
Author Information
1. 322100,浙江省东阳市人民医院病理科
- Keywords:
Receptors,estrogen/ME;
Receptors,progesterone/ME;
Breast neoplasms/ME/PA;
Receptor,epidermal growth factor/ME;
Immunohistochemistry
- From:
Journal of Chinese Physician
2018;20(4):521-523,527
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression and correlation of Fascin-1 and epidermal growth factor receptor (EGFR) in hormone receptor-positive breast cancer.Methods The immunohistochemical technique,EnVision method,was used to evaluate the expression of Fascin-1 and EGFR in 294 cases of hormone receptor-positive breast cancer,which contains 290 cases of estrogen receptor (ER) positive and 244 cases of progestrone receptor (PR) positive.According to ER,PR,Epidermal growth factor receptor 2 (HER2),and Ki-67 status,all cases of hormone receptor-positive breast cancer were categorized into 2 subtypes:160 cases of luminal A and 134 cases of luminal B.Results Fascin-1 and EGFR protein positive rates in hormone receptor-positive breast cancer was 13.9％ (41/294) and 30.6％ (90/294),respectively.Fascin-1 positive rate was significantly higher in EGFR positive cases (30.0％,27/90) than in EGFR negative cases (6.9％,14/204) (x2 =27.857,P =0.000).In the ER positive and PR positive cases,Fascin-1 positive rates were both significantly higher in EGFR positive cases than in EGFR negative cases (x2 =29.23,P =0.000;x2 =27.596,P =0.000,respectively).In the Luminal A and Luminal B subtype,Fascin-1 positive rates were also both significantly higher in EGFR positive cases than in EGFR negative cases (x2 =23.247,P=0.000;x2 =5.325,P=0.021,respectively).Conclusions EGFR signal pathway may positive regulate Fascin-1 expression in hormone receptor-positive breast cancer.
