The effect of preoperative anxiety on propofol EC50 for no-movement during painless gastroscopy

VernacularTitle:术前焦虑对丙泊酚抑制胃镜检查术体动的最低有效效应室浓度的影响
Author: Yiwen ZHANG ¹ ; Yanjing ZHANG ; Hanwen CHEN ; Jiyuan LI ; Zhiqiang CHEN ; Shile LIU ; Cuiyun ZHOU ; Zumin XING
Author Information

1. 南方医科大学顺德医院麻醉科
Keywords: Propofol/AD; Gastroscopy; Anxiety; Anesthesia
From: Journal of Chinese Physician 2018;20(4):493-495
CountryChina
Language:Chinese
Abstract: Objective To investigate the effect of preoperative anxiety on propofol EC50 for nomovement during Painless gastroscopy.Methods Thirty-one patients (without anxiety) and twenty-seven patients (with anxiety) undergoing gastroscopy under general anesthesia were enrolled on the study.Anesthesia was conducted with a target-controlled infusion (TCI) of propofol.The initial target effect-site propo fol concentration (Ceprop) was 5.0 μg/ml and was adjusted stepwise by 0.5 μg/ml by an up-down sequential method to reach no-movement.Results Propofol EC50 to induce no-movement was higher in patients with anxiety than those without anxiety (5.32 μg/ml,95％ CI:4.75-5.88 μg/ml vs 4.75 μg/ml,95％ CI:4.48-5.01 μg/ml,P ＜ 0.05).Conclusions During painless gastroscopy,patients with anxiety had a higher propofol EC50 for no-movement compared with those without anxiety when intravenous injected of fentanyl 0.1 μg/kg.