Research progress on the protective effects of polyphenols against doxorubicin-induced cardiotoxicity
10.3760/cma.j.issn.1008-1372.2018.03.049
- VernacularTitle:多酚类物质对抗阿霉素诱导的心肌毒性研究进展
- Author:
Hui LIN
1
;
Jie ZHANG
;
Liping MENG
;
Hangyuan GUO
Author Information
1. 325000,浙江省温州医科大学第一临床医学院
- Keywords:
Doxorubicin/AE;
Cardiomyopathies/CI;
Phenols/PD;
Review
- From:
Journal of Chinese Physician
2018;20(3):474-477
- CountryChina
- Language:Chinese
-
Abstract:
Doxorubicin is a major culprit in chemotherapy-induced cardiotoxicity,which is the chief limiting factor in delivering optimal chemotherapy to cancer patients.Although extensive efforts have been devoted,no chemical synthesized drugs or natural compounds are available to prevent the harmful action of doxorubicin without reducing its anti-cancer efficacy.Accumulative experimental evidence has shown that polyphenols can prevent doxorubicin-induced cardiotoxicity largely due to their anti-cancer and cardio protective properties.We elaborated on the potential mechanisms associated with doxorubicin-induced cardiotoxicity and reviewed published literatures about the protective effects of polyphenols on doxorubicin-induced cardiotoxicity to provide novel strategies for the study of cardioprotective drugs.
