Recent advances on microRNA-137 methylation in tumors
10.3760/cma.j.issn.1008-1372.2018.03.048
- VernacularTitle:MicroRNA-137甲基化改变在肿瘤中作用的研究进展
- Author:
Daohui GONG
1
;
Lingfeng MIN
Author Information
1. 225001,扬州大学临床医学院苏北人民医院呼吸科
- Keywords:
Neoplasms/GE;
MicroRNAs;
Methylation;
Review
- From:
Journal of Chinese Physician
2018;20(3):471-474
- CountryChina
- Language:Chinese
-
Abstract:
The aberrant expression of MicroRNA-137 (miR-137) is correlated with different tumors closely,miR-137 promoter methylation considered as one of the most important mechanisms through which miR-137 expression can be regulated.The degree of promoter methylation of miR-137 was significantly increased in tumors,but the frequencies varied.In addition,it correlated with different clinical and pathological characteristics in tumors.Furthermore,miR-137 promoter methylation indicated poor prognosis.miR-137 promoter methylation promoted the initiation and progression of tumors,it was of potential to be a biomarker and reversed the methylation status of miR-137 represented a novel strategy of cancer treatment.
