Effects of Chaihu-Longgu-Muli Decoction on the levels of blood superoxide dismutase and maiondiaidehyde in Temporal Lobe Epilepsy patients
10.3760/cma.j.issn.1008-1372.2018.03.010
- VernacularTitle:柴胡加龙骨牡蛎汤对颞叶癫痫患者SOD、MDA的影响
- Author:
Huiqiong XIAO
1
;
Ping YANG
;
Hongli PENG
Author Information
1. 湖南省脑科医院精神科、湖南中医药大学临床医学院
- Keywords:
Anticonvulsants/TU;
Bupleurum/TU;
Ostreidae/TU;
Epilepsy,temporal lobe/ZJ/ ME;
Superoxide dismutase/ME;
Malondialdehyde/ME
- From:
Journal of Chinese Physician
2018;20(3):357-359,363
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of Chaihu-Longgu-Muli Decoction (CLMD) on superoxide dismutase (SOD) and maiondiaidehyde (MDA) in patients with temporal lobe epilepsy (TLE).Methods 65 patients with TLE were randomly divided into Oxcarbazepine group (n =32) and Oxcarbazepine + CLMD group (n =33).After 28 d,the curative effect,SOD,MDA changes in serum and side effect were observed between two groups.Results The clinical effective rate in Oxcarbazepine + CLMD group was 87.8％,slightly higher than that of the Oxcarbazepine group(53.1％) (P ＜0.05).After treatment,serum SOD was significantly higher in the patients than before treatment in two groups,but serum MDA was significantly lower(P ＜ 0.05 or P ＜ 0.01),while the above changes were more obvious in the Oxcarbazepine + CLMD group (P ＜ 0.05).No statistically significant differences of side effect (P ＞ 0.05).Conclusions CLMD has higher curative effect with less side effect,which can lead to increase of the level of SOD and decrease of the level of MDA,and the mechanism is related to oxidative stress.
