Study of sleep quality and influence factors in patients with stable myasthenia gravis

VernacularTitle:稳定期重症肌无力患者的睡眠质量及其影响因素的研究
Author: Huiru FENG ¹ ; Ju LIU ; Hongxi CHEN ; Ziyan SHI ; Zhiyun LIAN ; Qin DU ; Hongyu ZHOU
Author Information

1. 四川大学华西医院神经内科
Keywords: Myasthenia gravis/CO; Sleep disorders/CO; Quality of life
From: Journal of Chinese Physician 2018;20(3):352-356
CountryChina
Language:Chinese
Abstract: Objective To investigate the sleep quality and influencing factors in patients with stable myasthenia gravis (MG).Methods From September 2015 to February 2017,151 cases of stable MG were enrolled in the department of neurology,West China Hospital,Pittsburgh sleep quality index (PSQI) was used to evaluate their sleep quality;Spearman analysis was used to analyze the influencing factors (clinical data,quality of life,anxiety and depression).Results Spearman test analysis showed that PSQI was positively correlated with age,duration,myasthenia gravis quality of life 15 (MG-QOL15),Hamilton Anxiety Scale 14 (HAMA14),Hamilton Depression Scale 24 (HADA24) (P ＜ 0.05).Stepwise regressionanalysis further revealed that life quality was the best predictor of reduced sleep quality (t =3.161,P =0.002),followed by anxiety (t =2.495,P =0.014) and age (t =2.356,P =0.020).Conclusions There are many influencing factors of stable MG wnich more attentions should be paid on.