The role of WNT/bate-catenin signaling pathway and miRNA in the development of breast cancer

VernacularTitle:WNT/β-catenin信号通路与miRNA在乳腺癌发生发展中的作用进展
Author: Qing FAN ¹ ; Wei ZHENG
Author Information

1. 421001,湖南衡阳南华大学
Keywords: Wnt proteins/ME; beta catenin/ME; MicroRNAs/ME; Breast neoplasms/ME
From: Journal of Chinese Physician 2018;20(2):311-314
CountryChina
Language:Chinese
Abstract: The breast cancer is the most common malignant tumor of women, and its treatments were widely explored.A lot of studies have confirmed that the abnormal activation of WNT/ beta-catenin signaling pathway and the abnormal expression of miRNA are closely related to the occurrence and development of breast cancer.miRNA could target the regulation of WNT/beta-catenin signaling pathway and affect the occurrence and development of many human tumors as an endogenous non-coding small molecule RNA.Therefore, the mechanism of WNT/beta-catenin signaling pathway in breast cancer and its interaction with miRNA may provide new ideas for the treatment of breast cancer.The article reviewed the composition of the WNT/beta-catenin signaling pathway and the role of this signaling pathway and its interaction with miRNA in the pathogenesis and progression of breast cancer.