Comparison of social function， adverse reaction and medication adherence of Paliperidone， Amisulpride and Olanzapine in patients with first-episode schizophrenia
10.3760/cma.j.issn.1008-1372.2018.02.015
- VernacularTitle:帕利哌酮缓释片、氨磺必利、奥氮平治疗首发精神分裂症患者的疗效、社会功能及服药依从性比较
- Author:
Zhiyong LAN
1
;
Weiming HU
;
Chi ZHANG
;
Lifeng ZHENG
;
Xiaofeng GAO
;
Wuyuan LAN
Author Information
1. 324000,浙江省衢州市第三医院精神科
- Keywords:
Antipsychotic agents/TU;
Isoxazoles/AA;
Isoxazoles/TU;
Benzodiazepines/TU;
Schizophrenia/DT;
Treatment outcome
- From:
Journal of Chinese Physician
2018;20(2):216-219
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the social function, adverse reaction and medication adherence of paliperidone, amisulpride, and olanzapine in patients with first episode schizophrenia.Methods A total of 96 patients with first episode of schizophrenia was randomly divided into three groups, with reference to random numbers, among which there were 32 in paliperidone group, 32 cases in amisulpride group, and 32 in olanzapine group.All the patients in all groups were assessed with negative and positive scale (PANSS), personal and social performance scale (PSP), drug attitude inventory (DAI) at baseline and the end of 6 months.Results (1) There was no significant difference in the therapeutic effect between three groups (P ＞ 0.05);(2) The scores of PSP and DAI were increased in three groups after treatment, and the difference was statistically significant compared to that before treatment (P ＜ 0.05).Conclusions Three drugs have similar efficacy in the treatment of first-episode schizophrenia, and there is no significant difference in improving medication compliance and social function.
