Currence pathogenic mechanism for weight loss in Parkinson disease

VernacularTitle:帕金森病患者体重减轻及其机制研究进展
Author: Yong YOU ¹ ; Weiting TANG
Author Information

1. 421001,湖南省衡阳市南华大学附属第一医院神经内科
Keywords: Parkinson disease/CO/PP; Weight loss; Review
From: Journal of Chinese Physician 2018;20(1):28-30,34
CountryChina
Language:Chinese
Abstract: Weight loss is common in non-motor symptoms in Parkinson disease (PD).It may predate motor symptom onset,and may be associated with the development of disease.However,it was less accounted of clinically.The pathophysiology of weight loss in PD is very complicated.This review discusses the pathogenesis of PD weight loss from dopaminergic dysfunction,energy expenditure/intake imbalance,central mechanisms of feeding behavior regulation,and neuroendocrine abnormalities.