Study on the relationship between insulin growth factor-1 and liver fibrosis in patients with chronic hepatitis C with type 2 diabetes mellitus
10.3760/cma.j.issn.1008-1372.2017.12.019
- VernacularTitle:胰岛素生长因子-1与合并2型糖尿病的慢性丙型肝炎患者肝纤维化的相关性
- Author:
Liyao ZHU
1
;
Jian ZHOU
;
Xingxiang LIU
;
Weiguang FENG
;
Weiping LU
Author Information
1. 淮安市第四人民医院肝病科
- Keywords:
Insulin-like growth factor I/ME;
Diabetes mellitus;
type 2/CO;
Hepatitis C;
chronic/CO/ME;
Liver cirrhosis/CO/ME
- From:
Journal of Chinese Physician
2017;19(12):1824-1827,1832
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between serum level of insulin growth factor 1 (IGF-1) and the degree of liver fibrosis in patients with chronic hepatitis C (CHC) complicated to type 2 diabetes mellitus (T2DM). Methods The cases were divided into CHC with T2DM (39 cases), CHC (96 cases), T2DM (60 cases), and healthy control (60 cases) groups. Their human data were collected and the fasting blood glucose, insulin and insulin-like growth factor-1 levels were detected, and the insulin resistance index ( HOMA-IR) wwer calculated. The serum levels of alanine transaminase ( ALT) , aspartate transaminase ( AST) , hepatitis C virus ( HCV) RNA load and HCV genotypes were detected simultaneously in patients with hepatitis C, and liver stiffness were measured ( LSM) by transient elastography ( TE) and aspartate aminotransferase-to-platelet ratio index ( APRI) score was performed. Results ⑴ There was no significant difference between CHC with T2DM group and CHC group in diabetes family history(P>0. 05), but two groups were significantly lower than that of T2DM group (P<0. 05). ⑵The levels of fasting insu-lin (FI) and HOMA-IR in CHC with T2DM group and T2DM group were significantly higher than those in the other two groups (P<0. 05), while the levels of IGF-1 in two groups were significantly lower than those in the CHC group, and were more lower than the control group (P<0. 05). ⑶Compared the serum ALT, AST and HCV RNA load between CHC with T2DM group and CHC group, there had no significant differ-ence (P>0. 05);however, the proportion of 1b genotype, LSM and APRI score of CHC with T2DM group were significantly higher than those in CHC group(P<0. 05). ⑷ The level of serum IGF-1 was negatively correlated with HOMA-IR, LSM and APRI in CHC with T2DM group (r= -0. 71, -0. 75, -0. 69, P<0. 01). Conclusions The degree of hepatic fibrosis and the damage of IGF-1 synthesis in CHC patients with T2DM were significantly higher than those in non T2DM patients, which might be related to the insulin resistance caused by 1b genotype HCV infection.
