The relationship of score of MoCA with urine ACR and PCX in patients with type 2 diabetic mild cognitive impairment
10.3760/cma.j.issn.1008-1372.2017.12.018
- VernacularTitle:2型糖尿病轻度认知功能障碍患者MoCA评分与尿白蛋白肌酐比值及足细胞标志蛋白的相关性
- Author:
Fan LIU
1
;
Aige YANG
;
Shanshan DONG
;
Yan KANG
;
Xinju JIA
;
Lina WANG
;
Huimin ZHOU
Author Information
1. 河北医科大学第一医院内分泌科
- Keywords:
Diabetes mellitus;
type 2/CO/ME;
Cognition disorders/CO/ME;
Creatinine/ME;
Al-bumins/ME;
Podocytes
- From:
Journal of Chinese Physician
2017;19(12):1820-1823
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of urine albumin-creatinine ratio ( ACR) and urina-ry podocalyxin (PCX) and the relationship of score of Montreal cognitive assessment (MoCA) with urine ACR and PCX in patients with type 2 diabetic mild cognitive impairment. Methods Sixty patients with type 2 diabetes mellitus were used as the control group, and 60 patients with type 2 diabetic mild cognitive impairment as the mild cognitive impairment ( MCI) group. The sex, age, and course of disease and years of education of patients were recorded, the fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), sys-tolic blood pressure ( SBP) , diastolic blood pressure ( DBP) , triglyceride ( TG) , total cholesterol ( TC) , low density lipoprotein ( LDL) , high-density lipoprotein ( HDL) , and urine ACR and PCX were measured, and the score of MoCA was assessed. Results The patients with type 2 diabetic nephropathy in the MCI group were significantly more than the control group (χ2 =73. 818,P<0. 01). The score of MoCA of the MCI group was significantly lower than the control group (P<0. 01), while urine ACR and PCX were high-er than the control group (P<0. 01). The score of MoCA was inversely associated with the urine ACR (r=-0. 868,P<0. 01) and PCX (r= -0. 785,P<0. 01), and those were the independent risk factors for the score of MoCA ( P<0. 01 ) . Conclusions The urine ACR and PCX were closely related to the cognitive function of type 2 diabetes mellitus, which can be used as the screening indexes of type 2 diabetic mild cog-nitive impairment.
