Prediction and Enlightenment of Optimal Single-batch Production for Five Oral Solutions in a Hospital
- VernacularTitle:某院5种口服溶液批生产量的优化预测与启示
- Author:
Xiuli XU
1
;
Yuhui YANG
;
Cuilian ZHANG
;
Biao WANG
;
Jia LI
Author Information
1. 中国医学科学院 北京协和医院药剂科 北京100730
- Keywords:
Hospital preparation;
Optimal prediction;
Single-batch production;
Clinical use during validity period;
Overall man-agement
- From:
China Pharmacist
2018;21(10):1872-1873,1891
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To predict the optimal single-batch production and annual production batches for five oral solutions in order to support equipment upgrade and control reasonable cost as well as provide reference for optimizing production management of new preparation room. Methods: The clinical use of the five oral solutions in four consecutive validity periods was retrospectively analyzed. Decision analysis was used to predict the optimal single-batch production and annual production batches for the five oral solutions. The weight coefficient was adjusted according to the clinical characteristics of each preparation. Results: The optimal single-batch produc-tion for the five oral solutions was five to seven times larger than the current scale while the annual production batches were greatly re-duced. In particular, compound ammonium chloride and glycyrrhiza oral solution ( formerly known as brown mixture) were reduced from 95 batches to 13 batches per year. Conclusion: The optimal prediction can provide reference for the appropriate adjustment of production scale of hospital preparations to lower the cost of single packaging production. At the same time, it is also beneficial to the overall management of production equipment selection and future scale design for new preparation room.
