Comparative Analysis of In-use Period after First Opening or Reconstitution of European Union Imported Sterile Products and Domestic Sterile Products in Our Hospital
- VernacularTitle:我院欧盟进口与国产无菌制剂说明书中药品开启或配制后使用期限的对比与分析
- Author:
Peipei QIAN
1
;
Kai CAO
;
Bingxin LAN
Author Information
1. 许昌市中心医院药学部 河南许昌461000
- Keywords:
Sterile product;
Reconstituted medicinal product;
Multiple-dose dosage form;
European import;
Domestic;
In-use period
- From:
China Pharmacist
2018;21(10):1828-1830
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To provide reference and suggestions for improving the in-use period information of sterile products after first opening or reconstitution in China. Methods: The package inserts of sterile products in our hospital were investigated. The sterile products needed to be reconstituted before use and with multiple-dose package were selected. The in-use period information of European imported sterile products and domestic sterile products were comparatively analyzed. Results: The presentation rate of in-use period in the package inserts of domestic sterile products was 32. 25% , which was less than 55. 56% of the other imported sterile products, and significantly less than 93. 55% of European imported sterile products. Conclusion: The relevant content of in-use period of sterile products after first opening or reconstitution is supplemented relatively late in China's stability testing guidance for drug substances and products, moreover, the specific technical proposals are absent. It is suggested that the drug administrative department and its techni-cal supportive agencies should improve the relevant guidance and guide pharmaceutical research enterprises and manufacturing enterpri-ses to carry out in-use stability studies, furthermore, gradually improve the relevant in-use period information in package inserts.
