Clinical Hemostasis Effect of Hemocoagulase for Injection in Scalp Incision in Craniocerebral Surgery
- VernacularTitle:注射用白眉蛇毒血凝酶用于颅脑手术头皮切口止血疗效观察
- Author:
Hongwu QI
1
;
Min QIAO
;
Yansong LIU
;
Weijun ZENG
;
Lizhao ZHANG
Author Information
1. 解放军白求恩国际和平医院神经外科 石家庄050082
- Keywords:
Hemocoagulase;
Craniotomy;
Scalp incision;
Hemorrhagic;
Hemostasis;
Coagulation function
- From:
China Pharmacist
2018;21(10):1807-1809
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the hemostasis effect of hemocoagulase for injection in scalp incision in craniocerebral surgery, and evaluate its effect on coagulation function and drug safety. Methods: Before undergoing craniotomy, 60 patients were randomly divid-ed into the study group and the control group. The study group was injected with hemocoagulase for injection at 1u im at the night before surgery, 1u im 1h before incision and 1u im 15min before incision. The control group was injected with 0. 9% saline at the same time with the same volume. The hemorrhagic volume, hemorrhagic volume per square decimeter, hemostatic time, blood coagulation and ad-verse events were tested and compared between the groups. Results: In the study group, the mean hemorrhagic volume was (37. 18 ± 2. 96)g, the mean hemorrhagic volume per square decimeter was (0. 23 ± 0. 16)g·cm-2and the mean hemostatic time was (125. 53 ± 36. 42)s. In the control group, the corresponding value was (60. 69 ± 2. 30) g, (0. 42 ± 0. 25) g·cm-2and (182. 72 ± 52. 29) s, re-spectively. The hemorrhagic volume, hemorrhagic volume per square decimeter and hemostatic time significantly decreased in the study group when compared with those in the control group (P<0. 05). No significant difference in blood coagulation and safety (P>0. 05). No adverse event was reported. Conclusion: Hemocoagulase for injection shows promising hemostasis effect with high safety, which can ensure craniocerebral surgery going well with shortened operation time.
