Determination of Crystal Type α in Glycine by Powder X-ray Diffraction
- VernacularTitle:粉末X射线衍射法测定甘氨酸原料药中α晶型的含量
- Author:
Danfeng LI
1
;
Jianping ZHU
;
Rigang LU
Author Information
1. 广西壮族自治区食品药品检验所 南宁530021
- Keywords:
Glycine;
X-ray powder diffraction;
Crystal content determination
- From:
China Pharmacist
2018;21(10):1759-1761
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To determine the content of crystal type α in glycine by X-ray power diffraction technique to provide evi-dence for the polymorphic research. Methods: A calibration curve was established by using the characteristic peak ratio of glycine form α at 2θ=19. 1° to form γ at 2θ=25. 4° as the quantitative parameter to determine the content of crystal type α. Results: The charac-terization figures of form α and form γ were obtained. The linear range of form α was 1%-99% (r=0. 996 7), and the average recov-ery was 102. 8% with the RSD of 4. 0% (n=9). Conclusion: X-ray powder diffraction method is a feasible analytical method for the quantitative determination of form α and form γ of glycine with simple,sensitive and accurate properties.
