Study on the Modeling Technology of Modified Zexie Plaster

VernacularTitle:加味泽泻贴膏成型工艺考察
Author: Zhibin YU ¹ ; Ying LI ; Qiong WANG
Author Information

1. 解放军第102医院江苏常州213003
Keywords: Modified Zexie plaster; Molding; Technology
From: China Pharmacist 2018;21(6):1130-1133
CountryChina
Language:Chinese
Abstract: Objective: To study the molding process of modified Zexie plaster. Methods: Sodium polyacrylate was used as the ad-hesive, carbomer as the emulsifier, glycerol as the humectant, and gelatin as the excipient. Orthogonal screening was applied to select the optimum formula and drug loading. Results: The significance order of the influencing factors was sodium polyacrylate > drug load-ing >gelatin >carbomer, and the best preparation process was A2B2C2D2, which was determined as 2. 5% sodium polyacrylate: 3% carbomer: glycerin: 12% gelatin: soluble starch: drug loading of 70: 6: 5: 15: 3: 9 (mass ratio). Conclusion: According to the optimum process route selected by orthogonal test, three batches of samples were tested, and the results showed that the process had good repro-ducibility, which is suitable for the industrial production.