Clinical Study of Sodium Creatine Phosphate in the Adjunctive Treatment of Patients with Hypertension Complicated with Acute Left Heart Failure
10.3969/j.issn.1008-049X.2018.06.025
- VernacularTitle:磷酸肌酸钠辅助治疗高血压并发急性左心衰竭患者的临床研究
- Author:
Wen XIAN
1
Author Information
1. 青海省交通医院急诊重症监护室 西宁810001
- Keywords:
Creatine sodium phosphate;
Hypertension;
Acute left heart failure;
Cardiotrophin-1;
Cytochrome C
- From:
China Pharmacist
2018;21(6):1048-1050,1060
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the efficacy of sodium creatine phosphate in the treatment of acute left heart failure caused by essential hypertension, and observe the changes of serum cytochrome C (Cyt C) and cardiotrophin-1 (CT-1). Methods: Seventy-three patients with essential hypertension complicated with acute left heart failure were randomly divided into the control group (n=35) and the observation group (n=38). The patients in the control group were given such treatment as oxygen uptake, diuresis, hypotension and dilatation of blood vessels. The patients in the observation group were given sodium creatine phosphate (1. 0mg, ivd, qd) on the basis of the control group. The changes of NYHA functional class, 6-minute walking distance and left ventricular ejection fraction (LVEF% ) before the treatment, 3 days and 7 days after the treatment were observed. The serum levels of NT-proBNP, ST2, Cyt C and CT-1 were measured by ELISA before the treatment and 3 days and 7 days after the treatment. Results: Compared with those be-fore the treatment, the cardiac function indices were improved after the treatment, and the levels of serum NT-proBNP, ST2, Cyt C and CT-1 all decreased (P<0. 05). Conclusion: Creatine sodium phosphate can effectively enhance the clinical efficacy in hypertension patients with acute left heart failure. The mechanism may be related to enhancing the energy metabolism of myocardial cells and reduc-ing cardiomyocyte apoptosis.
