Association of Genetic Polymorphism in ABCC2 with Cyclosporine Induced Liver Injury in Renal Transplant Recipients

VernacularTitle:肾移植受者中ABCC2基因多态性与环孢素导致肝损伤的相关性研究
Author: Fan ZHOU ¹ ; Fei LIU ; Lei XIONG ; Airong YU ; Di DU ; Yangwen AI ; Xueyi ZHOU ; Jing YAN ; Huawen XIN
Author Information

1. 解放军武汉总医院武汉430070
Keywords: Renal transplant recipients; ABCC2 Gene polymorphism; Cyclosporine; Liver injury
From: China Pharmacist 2018;21(6):1024-1028
CountryChina
Language:Chinese
Abstract: Objective: To investigate the association between ABCC2 gene polymorphisms and cyclosporine-induced liver injury in re-nal transplant recipients. Methods: The renal transplant recipients were divided into the liver injury group and the control group. Five single nucleotide polymorphisms ( rs4919395, rs2804398, rs4148394, rs4148397 and rs3740065) of ABCC2 were detected by high-throughput technique. The genotypes and haplotypes were analyzed between the groups. Results: There were 35 patients and 182 patients respectively in the liver injury group and the control group. No significant differences in alleles and genotypes were found between the groups (P>0. 05), and the SNP haplotypes showed no significant difference between the groups (P>0. 05). Conclusion: There is no association of ABCC2 polymorphisms (rs4919395, rs2804398, rs4148394, rs4148397 and rs3740065) with the liver injury induced by cy-closporine.