Anti-inflammatory and Immune Function Enhancing Effects of Schisandrin B in Mice
10.3969/j.issn.1008-049X.2018.06.006
- VernacularTitle:小鼠体内五味子乙素抗炎和增强免疫功能研究
- Author:
Haoran YU
1
;
Xiaoyu CHEN
;
Zhenkun TIAN
;
Lun WU
Author Information
1. 黑龙江中医药大学 哈尔滨150040
- Keywords:
Schisandrin B;
Mice;
Anti-inflammatory;
Immune function
- From:
China Pharmacist
2018;21(6):973-976
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To assess the anti-inflammatory and immunomodulatory activities of schisandrin B in mice. Methods: Kun-ming mice were randomly divided into 6 groups: the blank control group, the model control group, the positive control group( dexam-ethasone hydrochloride 5 mg·kg-1,levamisole hydrochloride 30 mg·kg-1), schisandrin B low (100 mg·kg-1), medium (200 mg ·kg-1) and high (400 mg·kg-1) dose groups. The inflammatory mice were induced by xylene and the immunosuppressed mice were induced by cyclophosphamide. The ear edema experiment, carbon clearance experiment and serum hemolysin experiment were per-formed with the swelling rate, swelling inhibition rate, carbon clearance index, phagocytic index, half hemolytic value, spleen index and thymus index as the investigation factors. Results: High dose and medium dose schisandrin B groups had significant inhibitory effect on mice ear edema when compared with the model control group(P<0. 05);There were significant differences between the high dose group and the positive group and there were significant differences in clearance index and phayxyitc index between high dose group and low dose group(P<0. 05), and high dose schisandrin B group had increased clearance index and phagocytic index in low immune function mice when compared with the model control group (P<0.05). Schisandrin B significantly increased HC50in low immune function mice when compared with the model control group (P<0. 01). Schisandrin B significantly increased the spleen index and thy-mus index in low immune function mice when compared with the model control group ( P<0. 01,and in a dose-dependent manner. Conclusion: Schisandrin B has significant anti-inflammatory and immune function enhancing effects.
