Progress in Clinical Application of Methadone in Cancer Pain Patients
- VernacularTitle:美沙酮在癌痛患者中的临床应用进展
- Author:
Xiaowei ZHENG
1
;
Gang TAO
;
Sisi KONG
;
Haiying DING
;
Ping HUANG
Author Information
1. 浙江省肿瘤医院 杭州310022
- Keywords:
Methadone;
Cancer pain;
Opioids;
Clinical application
- From:
China Pharmacist
2018;21(5):908-911
- CountryChina
- Language:Chinese
-
Abstract:
Opioids are the main treatment drugs for the patients with moderate and severe cancer pain,and methadone is one of opioid drugs. Compared with the other opioids, methadone has the advantages of low cost, high oral bioavailability and better effect on neuropathic pain. However, methadone also shows such disadvantages as prolonged QT interval and large individual variance in pharmacokinetics. Although the safety of methadone has no difference from the other opioids in the treatment of cancer pain,the lack of knowledge and experience still limits its clinical application. This article aimed to summarize the clinical application of methadone in cancer patients,so as to help clinicians understand and apply methadone better.
