Decoction Process Optimization for Xiaochengqi Decoction by Box-Behnken Response Surface Method
- VernacularTitle:Box-Behnken响应面法用于小承气汤的煎煮工艺优化
- Author:
Lihua SHI
1
Author Information
1. 嘉善县第一人民医院 浙江嘉兴314100
- Keywords:
Xiaochengqi decoction;
Rhein;
Aloe-emodin;
Synephrine;
Box-Behnken response surface method
- From:
China Pharmacist
2018;21(5):813-817
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To optimize the decoction process of Xiaochengqi decoction by Box-Behnken response surface method. Methods:Rhein,aloe-emodin and synephrine were chosen as the evaluation indices. After the material-liquid ratio, decocting frequency and decocting time were studied,Box-Behnken response surface method was used to optimize the three factors using the weighted calculation value of the extraction rate of above indicator components. Results:The best conditions were as follows:the material-liquid ratio was 1:10,the decocting frequency was 3,and the decocting time was 1.0 h. The deviation of measured value and predicted value was 1.15%. Conclusion:The best decocting conditions are promising and reliable.
