Preparation and Dissolution of Loratadine Nanosuspension Lyophilized Powder
- VernacularTitle:氯雷他定纳米混悬剂冻干粉制备及其溶出度考察
- Author:
Jian LYU
1
;
Hong ZHANG
;
Li WANG
;
Jiefang GAO
Author Information
1. 武汉大学人民医院药学部 武汉430060
- Keywords:
Loratadine;
Nanoparticle suspension;
Lyophilized powder;
Dissolution
- From:
China Pharmacist
2018;21(5):809-813
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare loratadine nanosuspension lyophilized powder (LTD-NLP) and investigate the dissolution and stability. Methods:LTD-NLP was prepared by an anti-solvent precipitation method; the particle size and morphology were characterized by a laser nanometer particle sizer and a transmission electron microscope (TEM). The optimal lyophilized protective agent was screened out; the dissolution and stability of LTD-NLP were determined by HPLC. Results:The average particle size of LTD-NLP was 175.6 nm with PDI of 0.200, and the zeta potential was -56.3 mV. The shape of LTD-NLP was spherical. The nanosuspension lyophilized with 10% sucrose presented optimal properties. The dissolution of LTD-NLP was greater than raw material, and LTD-NLP had good stability at 4℃. Conclusion:The anti-solvent precipitation method for LTD-NLP is simple,and the product is expected to become a new preparation of loratadine.
