Determination of Equilibrium Solubility and n-Octanol/Water Partition Coefficient of Cinnamon Acid and Cinnamaldehyde
- VernacularTitle:肉桂酸与桂皮醛的平衡溶解度及表观油水分配系数的测定
- Author:
Hongnian WU
1
;
Shihan TAN
;
Yuanqing WANG
;
Dan HUANG
;
Bin HAN
;
Ting CHEN
;
Kun LUO
;
Jianye YAN
Author Information
1. 湖南中医药大学药学院 长沙410208
- Keywords:
HPLC;
Cinnamon acid;
Cinnamaldehyde;
Equilibrium solubility;
n-Octanol/water partition coefficient
- From:
China Pharmacist
2018;21(5):801-804
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the equilibrium solubility and n-octanol/water partition coefficients (Papp)of cinnamon acid and cinnamaldehyde. Methods:The equilibrium solubility of cinnamon acid and cinnamaldehyde in different solutions was determined by HPLC,and their n-octanol/water partition coefficients were determined by a shaking flask method combined with HPLC-DAD. Results:When the pH of solution was 7.8,the equilibrium solubility of cinnamon acid was the largest,while that of cinnamaldehyde was the largest in pH 6.8 solution. The scopes of lgPappof cinnamon acid and cinnamaldehyde in different buffer solutions(pH 1.2-7.8) were -1.04-2.27 and 0.29-1.67, respectively, while those in n-octanol/water solvent were 0.85 and 1.26, respectively. Conclusion:The method is simple,accurate and fast to predicate the absorption of chemical components. In gastrointestinal physiological environment,cinnamaldehyde has good absorption, while cinnamon acid is with poor absorption in stomach and with better absorption in intestinal.
