Study on Tumor Drugs for Targeted Therapy Based on Micro-nanomotor
- VernacularTitle:基于微纳马达的肿瘤药物靶向治疗方法研究
- Author:
Mu LI
1
;
Ye YUAN
;
Fenglian YUE
;
Qiuyan ZHENG
;
Haiyan HUANG
;
Yanwen CHENG
Author Information
1. 哈尔滨医科大学附属第二医院药学部 哈尔滨150086
- Keywords:
Micro-nanomotor;
Micro-capsules;
Tumor drug;
Targeted therapy
- From:
China Pharmacist
2018;21(5):779-783
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the targeted motion and controllable release of tumor drugs based on micromotor. Methods:The directional movement of Janus micro-capsules was achieved through an external magnetic field,and the controllable release of tumor drugs was induced by near-infrared laser.Results:During the same period, the movement speed of the Janus capsules micromotor was the fastest(36.8 μm·s-1,approximately equalled to 3 body length·s-1) in 15% H2O2solution. Under the control of the external magnetic field, the Janus capsules micromotor could move along the scheduled trajectory close to the area of HeLa cells. Through the irradiation of near-infrared laser, the Janus capsules micromotor was broken and released the loaded drugs quickly. Conclusion:The Janus capsule micromotor studied in the paper can be used for targeted drug delivery safely and effectively,therefore,it shows good application prospect in the field of tumor diagnosis and treatment.
