Influence of Naogongtai Formula on Hippocampus Monoamine Neurotransmitters and Their Metabolites inRats in Elevated Plus-maze Test
- VernacularTitle:脑功肽组方对高架十字迷宫大鼠海马单胺类递质及其代谢物的影响
- Author:
Jian LEI
1
;
Guangli TAO
Author Information
1. 陆军军医大学新桥医院药学部 重庆400037
- Keywords:
Naogongtai formula;
Anti-anxiety;
Elevated plus-maze test;
Monoamine neurotransmitters
- From:
China Pharmacist
2018;21(5):772-775
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the influence of Naogongtai formula on hippocampus monoamine neurotransmitters and their metabolites in rats in elevated plus-maze test, and explore the mechanism of antihypertensive effect of brain tegument peptide. Methods:The effects of two doses of Naogongtai formula on the anxiety behavior of rats were observed by using the rat model of elevated malaria anxiety (EPM). The contents of monoamine neurotransmitters and their metabolites in hippocampus of rats were determined by HPLC-FLD. Results:Compared with those in the blank control group,the percents of open arms time and entries in the high dosage of Naogongtai formula group significantly increased (P < 0.05),and the percent of open arms entries in the low dosage of Naogongtai formula group significantly increased (P < 0.05). Compared with that in the blank control group, the content of 5-HT in the high dosage of Naogongtai formula group significantly decreased (P < 0.05) and the content of HVA significantly increased (P < 0.05). Conclusion:In the EPM test, Naogongtai formula shows a certain anti-anxiety effect, and the determination of monoamine neurotransmitters in hippocampus of rats may be related to the reduction of rat hippocampal 5-HT content.
