Stability Study of Ginkgo Biloba Extract Injection from Three Manufacturers in Two Varieties of Infusions
10.3969/j.issn.1008-049X.2018.03.040
- VernacularTitle:3个厂家银杏叶提取物注射液在两种溶媒中的稳定性考察
- Author:
Zefang YU
1
;
Haojing SONG
;
Xiao LI
;
Ying LI
;
Liju FAN
;
Zhanjun DONG
Author Information
1. 中南大学湘雅药学院 长沙410078
- Keywords:
HPLC-UV;
Ginkgo biloba extract injection;
Compatibility;
Stability
- From:
China Pharmacist
2018;21(3):504-508
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine and investigate the stability of ginkgo biloba extract injection from three different manufactur-ers respectively in 0.9% NaCl infusion and 5% glucose infusion under different conditions (room temperature, high temperature and light). Methods:Ginkgo biloba extract injection was mixed with the two kinds of infusions,and then divided into the normal tempera-ture group,the high temperature group and the light group. The appearance,insoluble particles,pH and content of flavonoids after the relevant treatment were investigated. The appearance and insoluble particles were tested according to the characteristics of the inspec-tion method described in Chinese Pharmacopoeia(2015 edition,volume IV,the general rule),and the content of flavonoids was detec-ted by HPLC-UV. Results:All the mixed solutions were yellow. No significant changes were found in the appearance,pH value,in-soluble particles and contents of quercetin and isorhamnetin in all the mixed solutions in 24 h. The pH value of the mixed solution with 5% glucose infusion was lower than that with 0.9% NaCl infusion,and all the pH values met the standard in Chinese Pharmacopeias. The kaemphenol content in the injection from Shenwei pharmaceutical company was higher than that from the other manufacturers, while the content of kaemphenol in all the injections was within the standard range. Conclusion:The quality of Ginkgo biloba extract injection from the three different manufacturers is stable under different conditions.
