Advances in Toll-like Receptor Signaling Pathway Induced by Pyrogens
10.3969/j.issn.1008-049X.2018.03.033
- VernacularTitle:热原诱导的Toll样受体信号传导通路研究进展
- Author:
Mingren WANG
1
,
2
;
Can WANG
;
Gang CHEN
Author Information
1. 复旦大学药学院 上海201203
2. 上海市食品药品检验所
- Keywords:
Pyrogen;
Inflammatory reaction;
Toll-like receptor;
Lipopolysaccharide;
Zymosan;
Lipteichoic acid
- From:
China Pharmacist
2018;21(3):480-484
- CountryChina
- Language:Chinese
-
Abstract:
Lipopolysaccharide(LPS),lipteichoic acid(LTA) and zymosan can be recognized by Toll-like receptors (TLRs) ex-pressing in the inflammatory cells membrane,such as macrophages,monocytes and endothelial cells,and then induce the secretion of pyrogenic cytokines followed by triggering inflammatory reaction. The signaling pathway mechanisms were summarized, including the extracellular signaling cascades from pyrogens to individual TLRs,and intracellular signaling cascades from TLRs to nucleus.
