Literature Analysis of Adverse Reactions Induced by Recombinant Human Erythropoietin in 149 Case Re-ports
10.3969/j.issn.1008-049X.2018.03.016
- VernacularTitle:重组人促红细胞生成素不良反应149例文献分析
- Author:
Lulu LI
1
;
Tiehua HUANG
;
Sibao WEI
;
Geng ZHANG
Author Information
1. 武汉市第一医院 武汉430022
- Keywords:
Recombinant human erythropoietin;
Adverse drug reactions;
Document analysis
- From:
China Pharmacist
2018;21(3):438-441
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the adverse reactions (ADRs) of recombinant human erythropoietin (rHuEPO) to provide refer-ence for clinical rational and safe medication. Methods:ADRs induced by rHuEPO reported at home and abroad were collected and analyzed in respects of age,gender,original illness, occurrence time, clinical manifestations and the results. Results: After the re-trieval,there were 149 cases of rHuEPO-induced ADRs with the damage of cardio vascular system, hematologic system, skin and its appendents accounting for 43.4%,20.8% and 12.7%,respectively. The top three main clinical manifestations of rHuEPO drug reac-tions were hypertension,pure red-cell aplastic anemia (PRCA) and hyperkalemia. The occurrence time should be paid particular at-tention in 5-12 weeks after the administration (43.0%). Conclusion:Physicians should be aware of rHuEPO-induced ADRs (espe-cially the occurrence time),pay attention to patients' medication education and avoid serious adverse reactions.
