Literature Review of Torsade de Pointes Induced by Ibutilide
- VernacularTitle:伊布利特致尖端扭转型室性心动过速的文献分析
- Author:
Bin SUN
1
;
Qi SUN
;
Qinghui SHANG
Author Information
1. 呼伦贝尔市人民医院 药学部 内蒙古呼伦贝尔021008
- Keywords:
Ibutilide;
Torsade de pointes;
Atrial fibrillation/flutter
- From:
China Pharmacist
2018;21(2):328-330
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the general patterns and characteristics of torsade de pointes(Tdp) associated with ibutilide and provide feasible suggestions and preventive measurements combined with the experience of pharmaceutical monitoring. Methods: The cases of TdP associated with ibutilide were retrieved from the literatures reported at home and abroad during January 1990 and April 2017,and the clinical data including gender,age,original diseases, dosage of drugs, injection time, TdP occurrence time, potassi-um,QTc and ECG monitoring before and after the medication, complications, treatment drugs and methods and conversion outcome were statistically analyzed. Results: A total of 9 cases were enrolled in the analysis. After the treatment with ibutilide withdrawal, electroversion and potassium and magnesium supplement, all the patients converted to sinus rhythm.Conclusion: Ibutilide must be prescribed very carefully in senile female patients complicated with extended QTc,low potassium,organic heart disease and heart fail-ure. With dosing interval,injection time or injection speed not compatible with the specification,the occurrence of TdP is significantly different,suggesting that clinical pharmacists strengthen the monitoring of injection time,speed,dosing interval and blood concentra-tion of ibutilide according to the instruction strictly.
