Efficacy of High-dose Morphine with Different Continuous Administration Routes:a Prospective Study in Pa-tients with Advanced Cancer Pain
- VernacularTitle:晚期癌痛患者不同方式大剂量吗啡持续给药疗效的前瞻性研究
- Author:
Yonggang LIU
1
;
Guohua WANG
;
Xudong ZHANG
;
Di DENG
Author Information
1. 武汉市江夏区第一人民医院肿瘤科 武汉430200
- Keywords:
Morphine injection;
Opioid transfer;
Patient-controlled analgesia;
Route of administration;
Advanced cancer pain
- From:
China Pharmacist
2018;21(2):291-294
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the efficacy of morphine with intravenous injection and subcutaneous injection in the treatment of advanced cancer,and explore the indications of different drug delivery methods for high-dose morphine. Methods: A prospective study was performed,and 46 cases of patients with advanced cancer pain were collected and divided into intravenous group and subcutaneous group according to the administration route. Pain was assessed during the administration,and the analgesic efficiency and the incidence of adverse reactions were observed to compare the efficacy and safety of two different ways to give high-dose morphine. Results:No statisti-cally significant differences were found in the number of outbreaks needed to be rescued,the frequency of morphine-induced drug deliver-y,the efficiency of analgesia after opioid transfer,and the incidence of opioid-related side effects between the groups (P>0.05). The dose of morphine in the subcutaneous group was higher than that of the intravenous group(P<0.05). Conclusion:The continuous ad-ministration of morphine with intravenous injection and subcutaneous injection can quickly,safely and effectively relieve pain. With the same analgesic efficacy,patients can choose appropriate administration route according to the dose of morphine, the influence degree of primary diseases and the individual will.
