Investigation and Analysis on the Drug-related Problems in Clinical Application of Antiepileptic Drugs in Hospitalized Patients of One Hospital
- VernacularTitle:某院住院患者抗癫痫药物临床应用药物相关问题的调查分析
- Author:
Feng CAO
1
;
Fangjian WU
Author Information
1. 长江航运总医院.武汉脑科医院药学科
- Keywords:
Antiepileptic drugs;
Drug-related problems;
Granada-Ⅱclassification;
Reasonable drug use
- From:
China Pharmacist
2018;21(2):268-272
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To discuss the causes and characteristics of drug-related problems(DRPs) of antiepileptic drugs by the in-vestigation of antiepileptic drugs' use in our hospital in order to provide reference for the rational clinical application of antiepileptic drugs. Methods:A retrospective analysis on 878 inpatients' records including antiepileptic drug application in our hospital from Janu-ary to December 2016 was carried out. The gender,age,etiology,application of antiepileptic drugs,usage,combination and adverse reactions were statistically analyzed in order to analyze the epidemiological characteristics of antiepileptic drugs in our hospital. At the same time,the necessity,safety and validity of the DRPs of antiepileptic drugs were studied by the international generic Spanish drug related research method(Granada-Ⅱclassification method). Results:Among the 878 cases,most were male patients(60.71%) and the proportion of patients over 50 years old was 69.02%. Patients with cerebrovascular diseases accounted for the most (323 cases, 36.79%),and 7 varieties of antiepileptic drugs were involved, and sodium valproate was with the largest proportion (489 cases, 51.75%). The DRPs were classified as DRP2(49 cases),DRP5(22 cases) and DRP6(8 cases). Conclusion:In view of the epi-demiological characteristics of antiepileptic drugs and DRPs specific issues in clinical applications, clinical pharmacists need to strengthen the intervention in DRPs of antiepileptic drugs in order to promote the safety and reasonability of clinical application.
