Monitoring Data Analysis of Valproic Acid in 233 Cases
- VernacularTitle:233例丙戊酸血药浓度监测结果分析
- Author:
Qiuyan YAN
1
;
Leting ZHU
;
Zhigang ZHAO
;
Weixing FENG
;
Shenghui MEI
;
Huiying ZHAO
Author Information
1. 北京市通州区新华医院 北京101105
- Keywords:
Valproic acid;
Therapeutic drug monitoring;
Drug-drug interaction;
Efficacy;
Adverse drug reaction
- From:
China Pharmacist
2018;21(2):264-267
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To provide basis for the rational use of valproic acid(VPA) in the patients with epilepsy through the analy-sis on the therapeutic monitoring data. Methods:The VPA plasma concentration and the other related information of 233 cases were analyzed retrospectively. Results:The total daily dose of VPA increased with age (P<0.05) in children group. Compared with that in adults group (19-50 years old),the target rate of VPA concentration was significantly higher in children group(4-14 years old) (P<0.001). VPA had similar antiepileptic effect in children and adults. Oral solution was the main dosage form for children and con-ventional tablets for adults. Children had higher target rate of VPA concentration than adults (P<0.05). Compared with the group with VPA alone,VPA combined with enzyme inducers such as carbamazepine,phenobarbital and phentoin significantly decreased the target rate of VPA concentration(P<0.001). Moreover,VPA combined with phenobarbital significantly decreased the total daily dose of VPA (P<0.05). Conclusion:With great inter-individual variance,VPA plasma concentration is associated with efficacy and side effects. Monitoring of VPA plasma concentration is useful to the individualized treatment of VPA.
