Stability Optimization and Evaluation of Exendin W/O/W Multiple Emulsion
- VernacularTitle:艾塞那肽W/O/W复乳稳定性优化及评价
- Author:
Jun WANG
1
;
Junqiao XING
Author Information
1. 武汉大学人民医院药学部 武汉430060
- Keywords:
Exendin;
Multiple emulsion;
Stability;
Freeze-drying
- From:
China Pharmacist
2018;21(2):250-253
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To improve the stability of exendin W/O/W multiple emulsion.Methods:The amount of electrolyte sodium chloride in the internal water phase and that of thickener PVP in the external water phase were both screened for exendin W/O/W mul-tiple emulsion,and the cryoprotectant in the freeze-drying process was optimized in order to further optimize the formula and preparation of exendin W/O/W multiple emulsion. Verification experiment was carried out to study the main properties of the optimized exendin W/O/W multiple emulsion in vitro. Results: The optimal quality volume percentage concentration of sodium chloride in the internal water phase was 0.10%,and that of PVP in the external water phase was 0.15%,and the best cryoprotectant was 10% mycose. The main in vitro properties of exendin W/O/W multiple emulsion showed no significant changes before the freeze-drying and after the rehy-dration. Conclusion:Through the optimization of the internal and external water phase of exendin W/O/W multiple emulsion,the sta-bility is enhanced,which lays foundation for the in vivo studies.
