Study on the Formula Composition Proportion of Pingwei Microemulsion Based on Pharmacodynamics
- VernacularTitle:基于药效学的平胃微乳处方配比优选实验研究
- Author:
Weigang LI
1
;
Zhaoyu CHEN
;
Yanyan ZHANG
;
Zongmin ZHANG
Author Information
1. 日照市中医医院 山东日照276800
- Keywords:
Pingwei powder;
Microemulsion;
Formula;
Pharmacodynamics
- From:
China Pharmacist
2018;21(2):237-241
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the compositions of Pingwei microemulsion through the formula screening and optimization, and carry out the pharmacodynamic validation. Methods:Three levels of mixed volatile oil,dregs water extract and glycyrrhizin were determined by single factor investigation. With the ulcer inhibition rate as an indicator,the orthogonal test was carried out to determine the amount of each component in the formula,and the pharmacodynamic validation was performed on the mouse model of gastric ulcer induced by indomethacin and the rat model of ulcer induced by ethanol hydrochloride.Results:The amount of each component in the formula was determined as follows:SFE-CO2mixed volatile oil of Atractylodes Lancea (Thunb.) DC., Magnolia officinalis Rehd. Et Wils. and Pericarpium Citri Reticulatae was 0.8 ml,glycyrrhizin was 60 mg,and the water extract after SFE-CO2extraction of Atrac-tylodes Lancea (Thunb.) DC.,Magnolia officinalis Rehd. Et Wils. and Pericarpium Citri Reticulatae was 2.0 g. Conclusion: The preparation process of Pingwei microemulsion is feasible,and Pingwei microemulsion has a good anti-ulcer effect,equalling to the posi-tive control Sanjiuweitai.
