Optimization of Preparation Technology of Rutin Nanoemulsion by Central Composite Design-Response Surface Method
- VernacularTitle:星点设计-效应面法优化芸香苷纳米乳的制备工艺
- Author:
Huiru ZHAO
1
;
Qiuyun GUO
;
Benjin JIANG
;
Hui JING
;
Yang YANG
;
Li GUAN
Author Information
1. 西安医学院药学院 西安710021
- Keywords:
Rutin;
Nanoemulsion;
Pseudoternary phase diagram;
Central composite design;
Response surface method
- From:
China Pharmacist
2018;21(2):204-208
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To optimize the preparation technology of rutin nanoemulsion. Methods:The pseudoternary phase diagram of rutin nanoemulsion under the condition of different Kmwas drawn. With the drug loading and the particle size as the independent var-iables,and the percent of oil and the weight ratio of surfactant to cosurfactant as the dependent variables, the blank formula of rutin nanoemulsion was optimized by central composite design-response surface method. Results:The optimal formula was as follows:the ra-tio of ethyl oleate, cremopher RH40,1,2-propanediol and water was 7: 13: 5: 25. The average particle size of the prepared rutin nanoemulsion was 26.51 nm,and the drug loading was 8.97 mg·ml-1. Conclusion:The central composite design-response surface method can obtain a good formula of rutin nanoemulison,and the model has a good predictive function.
