Determination of Equilibrium Solubility and Apparent Oil-water Partition Coefficients of Nicotinate-curcu-min Ester
- VernacularTitle:双烟酸姜黄素酯平衡溶解度及表观油水分配系数的测定
- Author:
Jingyi GUO
1
;
Qun HE
;
Yu GUO
;
Qinhui TUO
;
Duanfang LIAO
;
Jianye YAN
Author Information
1. 湖南中医药大学药学院 长沙410208
- Keywords:
Nicotinate-curcumin ester;
Equilibrium solubility;
Apparent oil-water partition coefficient;
HPLC
- From:
China Pharmacist
2018;21(2):197-200,214
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the equilibrium solubility and the apparent oil/water partition coefficients of nicotinate-curcu-min ester,so as to provide basis for the new formula design. Methods:Nicotinate-curcumin ester was dissolved in buffer solution with pH of 1.2-7.8. HPLC was used to detect the equilibrium solubility of nicotinate-curcumin ester in various solutions. The apparent oil/water partition coefficients in octanol-water and octanol-buffer solution system were measured by a shaking-flask method. Results:The solubility of nicotinate-curcumin ester in pH 6.8 was the highest. The apparent oil-water partition coefficients of nicotinate-curcumin ester in pH 1.2,5.8,6.5 and 7.8 were lgPapvalues within the range(lgPap=1.69-1.98) beneficial to the absorption in vivo. But in pH 2,5 and 6.8,the lgPapvalues were greater than 2 with strong lipophilicity. Conclusion:The equilibrium solubility as well as ap-parent oil/water partition coefficients of nicotinate-curcumin ester is greatly influenced by the pH value of media. In the pH value with relatively high solubility,lipophilicity is stronger,suggesting it is difficult to be absorbed by the body and needs to be further studied on dosage forms.
