Application of Powder Comprehensive Properties Characterization in Batch Changes of Cefuroxime Axetil
10.3969/j.issn.1008-049X.2018.01.045
- VernacularTitle:粉末综合性质表征在头孢呋辛酯批量变更中的应用
- Author:
Ruixiang HU
1
;
Wanli ZHAO
;
Huanxiang ZENG
Author Information
1. 国药集团致君(深圳)制药有限公司 广东深圳518110
- Keywords:
Cefuroxime axetil;
Stability and varying flow rate;
Compressibility;
Hear property;
Air inflation
- From:
China Pharmacist
2018;21(1):164-168
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the application of powder comprehensive properties characterization of cefuroxime axetil in batch changes .Methods:The stability and change of the powder before the batch change of cefuroxime axetil were measured by an FT 4 mul-tifunctional powder flow tester .The flow rate, compression rate, shear property, air inflation and air permeability were measured .The corresponding powder index was established .After the batch change , the above indices were detected to assess whether meeting the re-quirements.Results:The volume index of three batches of products after the batch change was within the optimal range .Conclusion:The batch changes of cefuroxime axetil have no effect on the smooth progress of cefuroxime axetil production , which provides a new rap-id verification method for preparation manufacturers .
