Study on Improvement of the Quality Standard for Bidouyan Granule
10.3969/j.issn.1008-049X.2018.01.044
- VernacularTitle:鼻窦炎颗粒质量标准的提高研究
- Author:
Hong ZHOU
1
;
Zhifu YANG
;
Xiaopeng SHI
;
Aidong WEN
;
Jinyi CAO
Author Information
1. 第四军医大学西京医院药剂科 西安710032
- Keywords:
Bidouyan granule;
TLC;
HPLC;
Quality standard
- From:
China Pharmacist
2018;21(1):162-164
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish the quality standard for Bidouyan granule .Methods: Scutellariae radix and Magnoloae flos were identified by TLC.The content of baicalin was determined by HPLC with a Kromasi 1 C18 column (250 mm ×4.6 mm,5 μm). The mobile phase consisted of methanol-water-phosphoric acid (45:55:0.2) at a flow rate of 1.0 ml· min-1, and the injection volume was 10μl.The detection wavelength was 280 nm and the column temperature was 30℃.Results:The spots in TLC were clear without any interference.The linear range of baicalin was 10.06 μg· ml-1-100.60 μg· ml-1 (r =1.0000).The average recovery was 96.3％,and RSD was 0.7％(n=6).Conclusion:The method is simple and specific with good repeatability , which can be used for the quality control of Bidouyan granule .
