Study Progress in Signaling through Thromboxane A2 Receptors in Platelet and Anti-platelet Drugs

VernacularTitle:血栓烷A2受体信号传导及相关抗血小板药物研究进展
Author: Shan WANG ¹ ; Peng LI ; Jianjiang FU ; Fuchao CHEN ; Huimin LIU ; Zhihao LI
Author Information

1. 湖北医药学院附属东风医院湖北十堰442000
Keywords: Platelets; Thromboxane A 2 receptor; Cells signaling transduction; Anti-platelet agents
From: China Pharmacist 2018;21(1):141-145
CountryChina
Language:Chinese
Abstract: Thromboxane A2 receptors (TPs) widely distribute in different organ systems and localize both on cell membranes and in intracellular structures.TPs are the members of seven-transmembrane G-protein-coupled receptor (GPCR) super family.Historical-ly, the involvement of TPs in platelet functions has received the greatest attention .TPs have the capacity to activate different signaling cascades which regulate platelet shape change , aggregation and secretion response .Currently , anti-platelet drugs primarily act on re-ceptors and /or signaling molecules in activation pathways .The signaling transduction of TPs in platelet contributes to the investigation of the effects of extracts of traditional Chinese medicine on antiplatelet aggregation and the exploration of the action mechanisms .