Influence of Cyclophosphamidum Used in Different Time during Menstrual Cycle on Ovary Anti-mullerian Hormone
10.3969/j.issn.1008-049X.2018.01.030
- VernacularTitle:环磷酰胺在月经周期不同时间用药对卵巢抗苗勒管激素的影响
- Author:
Zhu SHEN
1
;
Junjie BAO
;
Ying ZENG
;
Guowen CAO
;
Aiming SHI
;
Hong TAO
;
Bin CAO
;
Feng XU
Author Information
1. 苏州大学附属第二医院 药剂科 江苏苏州215004
- Keywords:
Cyclophosphamide;
Ovary anti-miillerian hormone;
Menstrual cycle
- From:
China Pharmacist
2018;21(1):121-123
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To preliminarily discuss the difference of ovary anti-miillerian hormone ( AMH) when cyclophosphamide is used in different time during menstrual cycle .Methods:Totally 30 young female patients with average age of (36 ±6.39) diagnosed as glomerular disease were treated with cyclophosphamide .According to the medication time , the patients were divided into follicular phase group and secretory phase group based on the property of menstrual cycle .Follicular phase group was treated with cyclophospha-mide during the first day and the eighth day of menstrual cycle .Secretory phase group was treated with cyclophosphamide after ovulato-ry time, namely the 14th day-the 16th day of menstrual cycle.AMH was detected before the drug treatment and 1st, 3rd, 6th and 10th cycles after cyclophosphamide treatment in the two groups .Results: AMH in the five periods had no statistic difference between the groups (P>0.05).There was significant difference in AMH before the treatment and after one-month treatment in the same group(P<0.05).AMH in different age groups showed statistic difference (P<0.05).Conclusion:There is no significant difference in AMH when cyclophosphamide is administrated in different time of menstrual cycle .However , ovarian function is impaired just by low dose cyclophosphamide (0.8g) with the first administration and will be recovered slowly at least half a year after the drug withdrawal .
