Study on the Water Extraction and Alcohol Precipitation Technology in tegrated of Xuanfei Zhike Granule
10.3969/j.issn.1008-049X.2018.01.022
- VernacularTitle:宣肺止咳颗粒的水提醇沉工艺考察
- Author:
Ling FAN
1
;
Jiazhen LUO
;
Xiaoqiong GU
;
Qinhua GU
;
Dongwei YU
Author Information
1. 苏州市中西医结合医院 江苏苏州215101
- Keywords:
Xuanfei Zhike granules;
Orthogonal test;
Hesperidin;
Tectoridin;
Yield of dry extract
- From:
China Pharmacist
2018;21(1):93-96
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To optimize the water extraction and alcohol precipitation technology of Xuanfei Zhike granule .Methods:Orthogonal test was used to investigate the effects of adding water , decocting time and boiling time on the water extraction , and the effects of relative density , alcohol precipitation concentration and alcohol precipitation time on the alcohol precipitation technology by taking comprehensive score including the amount of hesperidin , the amount of tectoridin and the yield of dry cream as the indices .Re-sults:The preferred water extraction technology was as follows: added 10 times water and extracted 1.5 h firstly, and then added 8 times water and extracted twice with 0.5 h for each.The preferred alcohol precipitation technology was as follows:concentrated the wa-ter extraction to a relative density of 1.05 (measured at 60℃), slowly added 95％ethanol to 80％alcohol solution and stored 18 h at low temperature .Conclusion:The optimal water extraction and alcohol precipitation technology is stable and feasible , which can pro-vide reference for the standardized production of Xuanfei Zhike granule .
