Study on the Preparation of Lansoprazole Enteric-coated Pellets Orally Disintegrating Tablets
10.3969/j.issn.1008-049X.2018.01.021
- VernacularTitle:兰索拉唑肠溶微丸型口崩片的制备研究
- Author:
Zhilong CHEN
1
;
Yuan ZENG
;
Lin HAO
;
Zhiqiang TAO
;
Jie YU
;
Hui LIU
Author Information
1. 解放军武汉总医院药剂科 武汉430012
- Keywords:
Lansoprazole;
Enteric-coated pellets;
Orally disintegrating tablets;
Acid resistance;
In vitro dissolution
- From:
China Pharmacist
2018;21(1):88-92
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare lansoprazole enteric-coated pellets and compress them into orally disintegrating tablets , and e-valuate the acid resistance in the acid stage and the in vitro dissolution in the buffer stage .Methods:Lansoprazole enteric-coated pel-lets were prepared by fluid bed coating technology , and the effects of the ratio of methacrylic acid copolymer dispersion to ethyl acrylate–methyl methacrylate copolymer dispersion , the concentration of triethyl citrate and the main pressure on the acid resistance in the acid stage and the in vitro dissolution in the buffer stage were evaluated .The similarity of the self-prepared orally disintegrating tablets and the reference preparation was evaluated by using f 2 similarity factor method .Results:The average particle size of microcrystalline cellulose core was 150-180 μm, the ratio of methacrylic acid copolymer dispersion to ethyl acrylate –methyl methacrylate copolymer dispersion was adjusted to 8:2, the enteric-coated weight was 30％, 20％triethyl citrate was used and the main pressure was controlled within the range of 10-16 kN.Lansoprazole enteric-coated pellets had sufficiently flexibility and stability against the compression force . The enteric coating did not break , showing good acid resistance .The dissolution similarity factor of the self-prepared orally disintegra-ting tablets and the reference preparation was greater than 50.Conclusion: Lansoprazole enteric-coated pellets orally disintegrating tablets have good acid resistance and high similarity for the in vitro dissolution, which can be further amplified .
