Pharmacokinetics and Tissue Distribution of Curcumin in Turmeric Capsules in Rats
10.3969/j.issn.1008-049X.2018.01.015
- VernacularTitle:姜黄胶囊中姜黄素在大鼠体内药动学和组织分布
- Author:
Yichang ZHANG
1
;
Yuan GONG
;
Huiqiong FANG
;
Juan LI
Author Information
1. 湖北中医药大学教育部中药资源和中药复方重点实验室 武汉430065
- Keywords:
Turmeric capsules;
Pharmacokinetics;
Curcumin;
HPLC;
Rat
- From:
China Pharmacist
2018;21(1):65-68
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the pharmacokinetics and tissue distribution characteristics of curcumin in turmeric capsules in rats.Methods:SD rats were given the capsules at the dose of 5 g· kg-1 , and plasma, liver, kidney, stomach and small intestine were withdrawn.Curcumin was determined by HPLC .Results:The results showed that the linear range of curcumin was 0.1-10μg· ml-1 .The metabolic results in vivo showed that t1/2 was (25.13 ±5.63) h, tmax was 0.50 h, Cmax was (0.44 ±0.01)μg· ml-1 , and AUC0-t was (2.11 ±0.04)μg· ml-1 · h.Meanwhile, curcumin could be detected out in gastrointestinal tract , liver and the other or-gans.Conclusion:Turmeric capsules can make curcumin rapidly absorbed and effectively distributed in various tissues of rats .The re-sults provide evidence for the clinical medication .
