Effects of the Process Parameters of Film Dispersion-ultrasonic Method on the Particle Diameters and En-capsulation Efficiency of Solid Lipid Nanoparticles of Nicotinate-curcumin
10.3969/j.issn.1008-049X.2018.01.004
- VernacularTitle:薄膜分散-超声法工艺参数对烟酸姜黄素酯纳米粒粒径及包封率的影响
- Author:
Qun HE
1
,
2
;
Guangyu CHEN
;
Qinhui TUO
;
Caipin ZHANG
;
Duanfang LIAO
Author Information
1. 湖南中医药大学药学院 长沙410208
2. 湖南省教育厅药学"十二五"重点学科
- Keywords:
Solid lipid nanoparticles of nicotinate-curcumin;
Film dispersion-ultrasonic method;
Particle diameters;
Encapsula-tion efficiency
- From:
China Pharmacist
2018;21(1):15-19
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effects of the process parameters of film dispersion-ultrasonic method on particle diameters and encapsulation efficiency of solid lipid nanoparticles of nicotinate-curcumin in order to obtain the process parameters resulting in smaller particle diameters and higher encapsulation efficiency .Methods: The content of nicotinate-curcumin was determined by HPLC.With the particle diameters and encapsulation efficiency of solid lipid nanoparticles of nicotinate -curcumin as the evaluation in-dicators , the process parameters of film dispersion-ultrasonic method were optimized by orthogonal experimental design and 95％confi-dence interval overlap method as the statistical analysis .Results:The optimum technological parameters of the solid lipid nanoparticles were as follows:the water bath temperature was 40℃and the rotation speed of eggplant bottle was 80 r· min-1 .The average particle size of solid lipid nanoparticles was 107.8 nm, polymer dispersity index ( PDI) was 0.583, and the encapsulation efficiency was 68.91％.Conclusion:The rotation speed of eggplant shaped bottle has notable influence on the particle diameters of solid lipid nanop -articles of nicotinate-curcumin prepared by film dispersion-ultrasonic method , while the water-bath temperature shows great influence on the encapsulation efficiency .Under the optimum conditions , it is possible to obtain the solid lipid nanoparticles with relatively smaller average particle diameters and higher encapsulation efficiency .
