Influences of Surfactants on Contact Angle of Pharmaceutical Excipients
- VernacularTitle:表面活性剂对辅料接触角的影响
- Author:
Xin YANG
1
;
Yukun DU
;
Wenjun TIAN
;
Hongxiao FAN
;
Qing DU
;
Yunjie DANG
Author Information
1. 河北医科大学药学院 石家庄050017
- Keywords:
Surfactant;
Contact angle;
Pharmaceutical excipients;
Wettability;
Critical micelle concentration
- From:
China Pharmacist
2017;20(11):2090-2092
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of surfactants on contact angle of pharmaceutical excipients and further study the effect of surfactants at different concentrations on the wettability of excipients and the effect of of surfactants and excipients at different proportions on the wettability of tablets. Methods:Different kinds of excipients were selected for tabletting,and surfactant solutions at different concentrations were prepared. The contact angle of the solutions on the surface of the tablets was measured by a contact angle tester. Results:The contact angle between the surfactants below the critical micelle concentrations and the tablets was the smallest and the wettability was the best. The change of the contact angle on the tablets with hydrophilic materials was less than that with hydropho-bic ones for most of the surfactants at the same concentration. Conclusion:After the addition of surfactants,the contact angle of excip-ient tablets significantly decreases, however, the contact angle will be stable after the amount of surfactants reaches a certain ratio, which shows significant reference value for tablet formula design.
