Experimental Research on the Detection Methods for Toddalolactone in Jinji Tablets
- VernacularTitle:金鸡片中毛两面针素检测方法考察
- Author:
Liang HU
1
;
Yinhong WANG
;
Zhenyu PAN
;
Ruilian LI
Author Information
1. 湖南省药品检验研究院 长沙410001
- Keywords:
Jinji tablets;
Zanthorμlum nitidum;
Toddalolactone;
TLC;
HPLC;
LC-MS
- From:
China Pharmacist
2017;20(11):2077-2079
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To identify toddalolactone and establish the analysis method for Jinji tablets.Methods: An Hypersil DBS C18column(250 mm×4.6 mm,5 μm) was used. The mobile phase consisted of acetonitrile-0.1% phosphoric acid solution. The flow rate was 0.8 ml·min-1and the detection wavelength was at 330 nm. Toddalolactone was identified by an LC-MS method and the re-sult was compared with that of the reference regent.TLC and HPLC analytical methods were used for analysis of toddalolactone.Re-sults:Totally 58 batches of Jinji tablets were tested,and the suspected samples were confirmed by HPLC-MS/MS.Toddalolactone was detected out from 20 batches of samples. Conclusion:The method is simple,rapid and accurate, which is able to detect toddalolac-tone quickly and effectively.
