Influence of Propofol Combined with Sevoflurane Anesthesia on Nitric Oxide/Endothelin-1 Ratio in the Pa-tients with Hepatic Lobectomy
- VernacularTitle:异丙酚复合七氟烷麻醉对肝叶切除术患者NO/内皮素-1比例的影响
- Author:
Chunxia LIN
1
;
Yuejun HUANG
;
Jian ZHANG
;
Chunyan WANG
Author Information
1. 成都市青白江区人民医院麻醉科 成都610300
- Keywords:
Propofol;
Sevoflurane;
Hepatic lobectomy;
Nitric oxide;
Endothelin-1
- From:
China Pharmacist
2017;20(11):1997-1998,2003
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the influence of propofol combined with sevoflurane anesthesia on nitric oxide/endothelin-1 ratio in the patients with hepatic lobectomy. Methods:Totally 84 patients with hepatic lobectomy were divided into two groups by the digital random method. Among them,42 patients received propofol combined with sevoflurane anesthesia as the observation group,and another 42 patients received midazolam anesthesia as the control group. Nitric oxide,endothelin-1,liver function indices(AST,ALT) and inflammatory factors (IL-1,IL-10,TNF-α) were detected respectively before hepatic portal occlusion,after hepatic portal occlu-sion and on postoperative third day. Results: Before hepatic portal occlusion, there were no significant differences between the two groups in above indicators (P >0.05). After hepatic portal occlusion, NO and IL-10 decreased significantly, while endothelin-1, AST,ALT,IL-1 and TNF-α increased significantly in the two groups.The differences between the two groups were statistically signifi-cant (P<0.01). All indices at postoperative 3 d in two groups recovered to the level before hepatic portal occlusion.Conclusion:Propofol combined with sevoflurane anesthesia contributes to adjusting nitric oxide/endothelin-1 ratio in the patients with hepatic lobec-tomy,which can improve liver function and inhibit the release of inflammatory cytokines.
