Transdermal Permeation of Compound Film Forming Gel in vitro
- VernacularTitle:复方成膜凝胶剂的体外透皮研究
- Author:
Li'na LIU
1
,
2
;
Ying CHEN
;
Ping YUAN
;
Fang QIU
Author Information
1. 中国人民解放军武汉总医院药剂科 武汉430070
2. 湖北中医药大学药学院
- Keywords:
Mupirocin;
Dyclonine;
Film forming gel;
Transdermal permeation in vitro
- From:
China Pharmacist
2017;20(11):1993-1996
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the preparation and in vitro release and transdermal absorption of compound film forming gel. Methods:The compound film forming gel was made from new types of film-forming materials. The in vitro release rate was determined by Franz diffusion cells. Results:The in vitro release rate of mupirocin and dyclonine from the compound film forming gel was 81.34% and 88.46%,the transdermal cumulative release amount was(192.73 ± 0.45) μg·cm-2and(103.58 ± 0.66) μg·cm-2,and the skin retention was (419.81 ± 1.48) μg·cm-2and (212.07 ± 1.81) μg·cm-2, respectively. Conclusion: The release of drug is nearly complete. The transdermal absorption test shows that about 30.26% mupirocin and 32.53% dyclonine can pass through skin, and about 65.91% mupirocin and 66.59% dyclonine are stored in skin. The preparation not only plays the role of bacteriostasis,but also promotes wound healing and analgesia.
